Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma
Ling He, Xiaohong Chen, Hui Ding, Daria J. Azizad, Carter Hoffman, Linda Azizi, Gazmend Elezi, Zian Zhuang, Anjelica M. Cardenas, Carlos Calderon, Mahya Mohammadi, Sophia Tate, Julian P. Whitelegge, Gang Li, Jonathan E. Zuckerman, , Frank Pajonk
The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.
bioRxiv · Apr 10, 2025 · PreprintNeuroscience