Julian P. Whitelegge

The paper identifies tear proteins associated with inflammation and RAGE/NLRP3 inflammasome activation in a Sjögren's disease mouse model.

The paper determines cryo-EM structures of dimeric PSII intermediates from cyanobacteria, revealing mechanisms of Mn4CaO5 cluster assembly/disassembly and photoinactivation.

This paper investigates the association between chlorpyrifos exposure and Parkinson's disease risk, finding increased odds of PD with long-term exposure and demonstrating causal mechanisms in animal models.

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.

This study identifies ZPR9 as a DUSP12 interactor and shows DUSP12 promotes cell cycle progression and protects cells from stress-induced apoptosis by de-phosphorylating ZPR9.

This paper shows that ethanolamine utilization via BMCs is essential for Fusobacterium nucleatum virulence, as BMC formation is regulated by a TCS and disruption reduces pathogenicity in a mouse model.

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

This study identifies Drosophila mojavensis as a species with elevated sleep need compared to D. melanogaster, linking sleep patterns to survival in extreme environments.

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.