Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces
Sophie Kong, Trenton M. Peters-Clarke, Corleone S. Delaveris, Paul J. Phojanakong, Veronica Steri, James A. Wells
This study identifies PAD4 substrates and their citrullination effects, showing PAD4 induces cell migration and generates citrullinated peptides that can trigger autoantibodies.
bioRxiv · Jan 6, 2026 · PreprintCancer Biology