Trenton M. Peters-Clarke

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

Structural and mechanistic analyses reveal collaborative regulation of HSF1 by the Hsp70-Hsp90 chaperone systems

This study reveals how HSF1 is regulated by Hsp70 and Hsp90 chaperones through structural and mechanistic analyses, showing Hsp90's role in maintaining HSF1 in a pre-activated state.

High-resolution photocatalytic crosslinking of protein neighborhoods using contact-dependent antibody mapping (contactMAP)

The paper introduces contactMAP, a photocatalytic crosslinking method for high-resolution mapping of protein neighborhoods, showing it rivals or outperforms existing photo-PLP methods.

Targeted shedding of extracellular membrane proteins by induced protease recruitment

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.

The paper expands the kineTAC toolbox by creating 81 new cytokine receptor-targeting chimeras for cell-type-specific extracellular protein degradation.

Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces

This study identifies PAD4 substrates and their citrullination effects, showing PAD4 induces cell migration and generates citrullinated peptides that can trigger autoantibodies.

Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

Highly fucosylated N-glycans at the synaptic vesicle and neuronal plasma membrane

The paper characterizes N-glycosylation at synaptic vesicles and neuronal plasma membranes in mouse brain, identifying highly fucosylated N-glycans enriched in synaptic vesicles.

Detection of Discordant Peptide Quantities in Shotgun Proteomics Data by Peptide Correlation Analysis (PeCorA)

The paper introduces PeCorA, a method to detect discordant peptide quantities in shotgun proteomics data, identifying 15% of proteins with one discordant peptide in mouse microglia.