Author

Sophie Vieweg

École Polytechnique Fédérale de Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Anass ChikiiD· 2 shared Hilal Ahmed LashueliD· 2 shared Urszula Cendrowska· 2 shared Alfredo Alexander‐KatziD· 1 shared Anne‐Laure Mahul‐MellieriD· 1 shared Francesco Simone RuggeriiD· 1 shared Francesco StellacciiD· 1 shared Francesco TavantiiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

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2 papers

Recent·Most cited

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

Sophie Vieweg, Anne‐Laure Mahul‐Mellier, Francesco Simone Ruggeri, Nathan Riguet, Sean M. DeGuire, Anass Chiki, Urszula Cendrowska, Giovanni Dietler, Hilal Ahmed Lashuel

This study shows that the Nt17 domain regulates Httex1 aggregation, toxicity, and cellular uptake through its conformation and interaction with polyQ repeats.

Journal of Molecular Biology · Sep 4, 2021Peer-reviewedNeuroscience

Unraveling the Complexity of Amyloid Polymorphism Using Gold Nanoparticles and Cryo-EM

Urszula Cendrowska, Paulo Jacob Silva, Nadine Ait‐Bouziad, Marie Müller, Zekiye P. Güven, Sophie Vieweg, Anass Chiki, Lynn Radamaker, Senthil T. Kumar, Marcus Fändrich, Francesco Tavanti, Maria Cristina Menziani, Alfredo Alexander‐Katz, Francesco Stellacci, Hilal Ahmed Lashuel

This paper introduces gold nanoparticles labeled with 11-mercapto-1-undecanesulfonate to visualize and characterize amyloid polymorphism using cryo-EM, revealing structural differences between in vivo and in vitro amyloid fibrils.

Proceedings of the National Academy of Sciences · Mar 11, 2020Peer-reviewedNeuroscience