Author

Sean M. DeGuire

École Polytechnique Fédérale de Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anass ChikiiD· 3 shared Hilal Ahmed LashueliD· 3 shared Anne‐Laure Mahul‐MellieriD· 2 shared Francesco Simone RuggeriiD· 2 shared Giovanni DietleriD· 2 shared Urszula Cendrowska· 2 shared Ahmed SadekiD· 1 shared Christian IseliiD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 30, 2022

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

Hilal Ahmed Lashuel, Anne‐Laure Mahul‐Mellier, Salvatore Novello…·Nicolas Guex

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

2 citations

mouseproteomics

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NeuroscienceJournal of Molecular BiologyPeer-reviewedSep 4, 2021

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

Sophie Vieweg, Anne‐Laure Mahul‐Mellier, Francesco Simone Ruggeri…·Hilal Ahmed Lashuel

This study shows that the Nt17 domain regulates Httex1 aggregation, toxicity, and cellular uptake through its conformation and interaction with polyQ repeats.

33 citations

protein structureexperimental assay

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NeuroscienceJournal of Biological ChemistryPeer-reviewedSep 5, 2018

N-terminal phosphorylation of Huntingtin: A molecular switch for regulating Htt aggregation, helical conformation, internalization and nuclear targeting.

Sean M. DeGuire, Francesco Simone Ruggeri, Mohamed-Bilal Fares…·Hilal Ahmed Lashuel

This study investigates how phosphorylation at S13 and S16 of Httex1 affects its structure, aggregation, and subcellular localization, revealing a phosphorylation-dependent switch that regulates its function.

83 citationstop 3%

protein structureexperimental assay

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