Nadine Ait‐Bouziad

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

This paper introduces gold nanoparticles labeled with 11-mercapto-1-undecanesulfonate to visualize and characterize amyloid polymorphism using cryo-EM, revealing structural differences between in vivo and in vitro amyloid fibrils.

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.