Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction
Anne E Buglione, David M. Small, Nathaniel H. Allan‐Rahill, Tyler Locke, Laila M. Abd Elmagid, Rachel Kim, Soseh Hovasapian, Adina A. Mistry, Sofia A. Vaquerano, Chris B. Schaffer, Nozomi Nishimura
This study identifies neutrophil arrest in myocardial capillaries as a driver of hypoxia and impaired diastolic function in a mouse model of HFpEF, showing that reducing neutrophil arrest improves cardiac function.
bioRxiv · Feb 17, 2025 · PreprintPhysiology