Author

Tyler Locke

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Adina A. Mistry· 1 shared Amanda Ferrante· 1 shared Anne E BuglioneiD· 1 shared Chris B. SchafferiD· 1 shared David M. SmalliD· 1 shared Deng LiiD· 1 shared Laila M. Abd ElmagidiD· 1 shared Michael N. Weaver· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

Adina A. Mistry

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2 papers

Recent·Most cited

Conformational Changes of Surfactant Protein B Due to the Alveolar Air/Liquid Interface Using Molecular Dynamics

Tyler Locke, Amanda Ferrante, Deng Li, Michael N. Weaver, Mona S. Minkara

This study uses molecular dynamics to analyze conformational changes in surfactant protein B at the alveolar air/liquid interface, revealing stability of the closed conformation and hydrophobic-driven changes in the open conformation.

Journal of Molecular Modeling · Dec 4, 2025Peer-reviewedBiochemistry

Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction

Anne E Buglione, David M. Small, Nathaniel H. Allan‐Rahill, Tyler Locke, Laila M. Abd Elmagid, Rachel Kim, Soseh Hovasapian, Adina A. Mistry, Sofia A. Vaquerano, Chris B. Schaffer, Nozomi Nishimura

This study identifies neutrophil arrest in myocardial capillaries as a driver of hypoxia and impaired diastolic function in a mouse model of HFpEF, showing that reducing neutrophil arrest improves cardiac function.

bioRxiv · Feb 17, 2025 · PreprintPhysiology