Nozomi Nishimura

This study uses adipose-mimetic hydrogels to show that soft mechanical cues from adipocytes enhance breast cancer cell invasion by altering ECM structure and cellular confinement.

This study identifies reprogrammed neutrophils with impaired transit mechanics as a driver of multi-organ capillary stalling after stroke, showing therapeutic potential through Fgr inhibition.

This study uses THG microscopy to track subcortical myelin degradation in a mouse MS model, finding increased intranodal distances and a new quantitative metric for early detection.

This study shows psilocybin prolongs neurovascular coupling in mouse visual cortex, affecting blood flow without altering neural responses, and suggests implications for interpreting human neuroimaging data.

This study identifies neutrophil arrest in myocardial capillaries as a driver of hypoxia and impaired diastolic function in a mouse model of HFpEF, showing that reducing neutrophil arrest improves cardiac function.

This paper develops magnetogenetic tools to bidirectionally regulate specific neuronal circuits in vivo using magnetic fields and shows their efficacy in motor control and Parkinson's models.

In a mouse model of focal epilepsy, sub-surface laser-produced cuts encircling the seizure focus attenuate propagation without behavioral impairment.

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

The paper identifies differential regulation of specific granulin peptides and their glycosylation patterns in relation to lysosomal protease activity and physiological/pathological conditions.

This study shows that inhibiting VEGF signaling in AD mice reduces leucocyte adhesion in brain capillaries, increases blood flow, and improves BBB integrity.

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.

This study investigates whether aspirin affects microhemorrhage size in young and aged mice, finding no significant difference compared to controls.