Author

Spencer A. Tye

University of Wisconsin–Madison

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Biology Disciplines

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adele K. AddingtoniD· 1 shared Alexey V. ZaitseviD· 1 shared Anna S. NichenkoiD· 1 shared Braeden J. Kraft· 1 shared Charles P. NajtiD· 1 shared Daniel S. Braxton· 1 shared Haiyan Zhang· 1 shared John R. Brown· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Adele K. AddingtonORCID

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1 paper

Recent·Most cited

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Orion S Willoughby, Anna S. Nichenko, Matthew H. Brisendine, Niloufar Amiri, Shelby N. Henry, Daniel S. Braxton, John R. Brown, Braeden J. Kraft, Kalyn S. Jenkins, Adele K. Addington, Alexey V. Zaitsev, Steven T. Burrows, Ryan P. McMillan, Haiyan Zhang, Spencer A. Tye, , Joshua C. Drake

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

Molecular Metabolism · Nov 25, 2025Peer-reviewedPhysiology