Alexey V. Zaitsev

This study investigates whether PERM1 regulates systolic cardiac function by conducting a large-scale echocardiography analysis with increased sample size, finding significant differences in cardiac parameters between Perm1-KO and WT mice.

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

AAV9-PERM1 gene therapy preserves cardiac function in a mouse model of pressure overload-induced heart failure by maintaining mitochondrial biogenesis, respiration, and contractility.