Haiyan Zhang

Spatial transcriptomics reveals site-specific cellular and metabolic heterogeneity in bladder carcinoma in situ

This study uses spatial transcriptomics to show that bladder carcinoma in situ has spatially structured cellular and metabolic heterogeneity within a single patient.

The Capillary endothelial cell-governed niche sustains angiogenesis in proliferating infantile hemangioma via multilayer stromal support

This study identifies capillary endothelial cells and their interactions with pericytes and mesenchymal stem cells as key drivers of angiogenesis in infantile hemangioma.

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention

The paper reports high-frequency off-target mutagenesis in Arabidopsis using CRISPR/Cas9 despite high specificity scores and presents strategies to prevent it.

Comparative transcriptome analysis by deep RNA sequencing at early stage of skin pigmentation in goats (Capra hircus)

The paper uses RNA sequencing to compare gene expression in dark- and white-skinned goats during early skin pigmentation, identifying differentially expressed genes and novel transcripts related to melanogenesis.