Author

Spencer Hahn

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ahmed HasaniD· 1 shared Aleksandra OlowiD· 1 shared Barbara Rath· 1 shared Bruce Huang· 1 shared Cindy Li· 1 shared David Bauché· 1 shared Essam MetwallyiD· 1 shared Gukhan KimiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ahmed HasanORCID

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1 paper

Recent·Most cited

YAP/TEAD4-regulated placental alkaline phosphatases ALPP and ALPPL2 are immunosuppressive ectonucleotidases modulated by MAPK inhibitors

J MARTIN, Bruce Huang, Tobias Ehrenberger, Ahmed Hasan, Michelle T. Dow, Weng Hua Khoo, Romain Pacaud, Essam Metwally, Katherine Porth, Gukhan Kim, Sawyer McKenna, Cindy Li, Nicholas Ho, Khoa Nguyen, Spencer Hahn, , David Bauché

This study identifies YAP/TEAD4 as a regulator of ALPP/L2 expression and shows that MAPK inhibitors enhance their expression, improving ADC efficacy through immunomodulation.

bioRxiv · Oct 15, 2025 · PreprintCancer Biology