Author

Aleksandra Olow

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0002-0113-8306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Ahmed HasaniD· 1 shared Antonio RullaniD· 1 shared Barbara Rath· 1 shared Bruce Huang· 1 shared Cindy Li· 1 shared David Bauché· 1 shared David NovoiD· 1 shared Deborah Schneider-LuftmaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Ahmed HasanORCID

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2 papers

Recent·Most cited

Multicellular Calcium Waves in Cancer-Associated Fibroblasts Regulate Neuronal Mimicry and Anisotropy Leading to Immune Exclusion

Giovanni Giangreco, Zoe Ramsden, Antonio Rullan, Steven Hooper, David Novo, Joana Leitão-Castro, Probir Chakravarty, Marta Milan, Hamid Mohammadi, Sandra Llop, Marc Juarez, Deborah Schneider-Luftman, Marc Oliva, Laia Alemany, Mihaela Angelova, , Erik A. Sahai

The paper identifies neuronal mimicry in cancer-associated fibroblasts driven by calcium waves, leading to immune exclusion, and shows that blocking this process restores immune control.

bioRxiv · Oct 23, 2025 · PreprintCancer Biology

YAP/TEAD4-regulated placental alkaline phosphatases ALPP and ALPPL2 are immunosuppressive ectonucleotidases modulated by MAPK inhibitors

J MARTIN, Bruce Huang, Tobias Ehrenberger, Ahmed Hasan, Michelle T. Dow, Weng Hua Khoo, Romain Pacaud, Essam Metwally, Katherine Porth, Gukhan Kim, Sawyer McKenna, Cindy Li, Nicholas Ho, Khoa Nguyen, Spencer Hahn, , David Bauché

This study identifies YAP/TEAD4 as a regulator of ALPP/L2 expression and shows that MAPK inhibitors enhance their expression, improving ADC efficacy through immunomodulation.

bioRxiv · Oct 15, 2025 · PreprintCancer Biology