Discovery and Engineering of Retrons for Precise GenomeEditing
Jesse Buffington, Hung‐Che Kuo, Kuang Hu, You-Chiun Chang, Kamyab Javanmardi, Brittney Voigt, Yi-Ru Li, Mary E. Little, Sravan K. Devanathan, Blerta Xhemalçe, Ryan S. Gray, Ilya J. Finkelstein
This paper discovers and engineers retron-based gene editors for precise genome editing in mammalian cells and vertebrates, achieving high efficiency with novel reverse transcriptases and delivery strategies.
Nature Biotechnology · Oct 23, 2025Peer-reviewedMolecular Biology