Author

You-Chiun Chang

The University of Texas at Austin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Hung‐Che KuoiD· 2 shared Ilya J. FinkelsteiniD· 2 shared Blerta XhemalçeiD· 1 shared Brittney VoigtiD· 1 shared Carlos ArguelloiD· 1 shared Chia‐Wei ChouiD· 1 shared Daphne SahayaiD· 1 shared Jesse BuffingtoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Hung‐Che KuoORCID

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Author profile →

2 papers

Recent·Most cited

Structural Basis for Target Discrimination and Activation by Cas13d

Chia‐Wei Chou, Selma Sinan, Hung‐Che Kuo, You-Chiun Chang, Carlos Arguello, Daphne Sahaya, Rick Russell, Ilya J. Finkelstein

This study reveals the structural basis for Cas13d's target discrimination and activation through cryo-EM structures and kinetic analysis of matched and mismatched RNA targets.

Science Advances · Aug 19, 2026Peer-reviewedBiochemistry

Discovery and Engineering of Retrons for Precise GenomeEditing

Jesse Buffington, Hung‐Che Kuo, Kuang Hu, You-Chiun Chang, Kamyab Javanmardi, Brittney Voigt, Yi-Ru Li, Mary E. Little, Sravan K. Devanathan, Blerta Xhemalçe, Ryan S. Gray, Ilya J. Finkelstein

This paper discovers and engineers retron-based gene editors for precise genome editing in mammalian cells and vertebrates, achieving high efficiency with novel reverse transcriptases and delivery strategies.

Nature Biotechnology · Oct 23, 2025Peer-reviewedMolecular Biology