Ryan S. Gray

Genetic interaction between Adgrg6 and Sox9 reveals a feedforward mechanism for postnatal spinal stability

The paper identifies a genetic interaction between Adgrg6 and Sox9 that contributes to spinal stability and AIS-like pathology in mice.

CiliaIO: Machine learning reveals spatial patterns of cilia beating dynamics in the zebrafish spinal cord

CiliaIO uses machine learning to quantify cilia beating dynamics in zebrafish spinal cord, revealing regional waveform differences and subtle defects in a bbs2 mutant.

Discovery and Engineering of Retrons for Precise GenomeEditing

This paper discovers and engineers retron-based gene editors for precise genome editing in mammalian cells and vertebrates, achieving high efficiency with novel reverse transcriptases and delivery strategies.

VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution

VerteBrain maps conserved brain protein interactions across five vertebrate species, revealing novel complexes and disease mechanisms.

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

Spatial Transcriptomics Reveals the Requirement of ADGRG6 in Maintaining Chondrocyte Homeostasis in Mouse Growth Plates

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

A conserved regulation of cell expansion underlies notochord mechanics, spine morphogenesis, and endochondral bone lengthening

This study identifies inppl1a as a gene regulating cell expansion in zebrafish notochord, spine morphogenesis, and endochondral bone lengthening, revealing a conserved mechanism across species.

Kif6 regulates cilia motility and polarity in brain ependymal cells

The paper investigates the role of Kif6 in ependymal cilia motility and polarity, finding that its loss causes decreased cilia movement and hydrocephalus in mice.

ADGRG6 promotes adipogenesis and is involved in sex-specific fat distribution

This study identifies ADGRG6 as a gene involved in adipogenesis and sex-specific fat distribution, showing its potential as a therapeutic target for metabolic disease.

A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

This study identifies Adgrg6 as essential for maintaining spine alignment by regulating biomechanical properties and gene expression in connective tissues, offering therapeutic insights for adolescent idiopathic scoliosis.

Postembryonic screen for mutations affecting spine development in zebrafish

This study identifies mutations affecting spine development in zebrafish, revealing new candidate genes for human spine disorders like scoliosis.

Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulome

This study identifies AIS-associated genes and regulatory elements through RNA-seq and ChIP-seq in human and mouse tissues, revealing pathways involved in chondrogenesis and connective tissue maintenance.

A Comparative Study of the Turnover of Multiciliated Cells in the Mouse Trachea, Oviduct and Brain

The paper compares turnover rates of multiciliated cells in the mouse trachea, oviduct, and brain, finding similar rates in the trachea and oviduct but slower turnover in brain ependymal cells.

Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis

This study shows PRMT5 regulates terminal hypertrophic chondrocyte differentiation and models infantile idiopathic scoliosis in mice.

Homeostasis of the intervertebral disc requires regulation of STAT3 signaling by the adhesion G-protein coupled receptor ADGRG6

This study identifies ADGRG6 as a regulator of intervertebral disc homeostasis through STAT3 signaling, showing that inhibiting STAT3 reduces disc degeneration in a mouse model.

The Reissner Fiber is Highly Dynamic in vivo and Controls Morphogenesis of the Spine

This study shows that the Reissner fiber, secreted by the subcomissural organ in zebrafish, is essential for spine morphogenesis and its loss leads to scoliosis.

Mutations in Kinesin Family Member 6 Reveal Specific Role in Ependymal Cell Function and Human Neuro-Cranial Development

The paper identifies a homozygous KIF6 mutation in a child with neurocranial defects and intellectual disability, showing its role in ependymal cell cilia maintenance and neuro-cranial development through mouse and zebrafish models.