Hung‐Che Kuo

Structural Basis for Target Discrimination and Activation by Cas13d

This study reveals the structural basis for Cas13d's target discrimination and activation through cryo-EM structures and kinetic analysis of matched and mismatched RNA targets.

Transcription factor collaboration enables precise T cell state engineering

The paper identifies transcription factor collaborations that shape CD8+ T cell states and demonstrates how engineering these interactions can influence cell fate for therapeutic applications.

Discovery and Engineering of Retrons for Precise GenomeEditing

This paper discovers and engineers retron-based gene editors for precise genome editing in mammalian cells and vertebrates, achieving high efficiency with novel reverse transcriptases and delivery strategies.

Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d

The paper introduces RNA-CHAMP, a platform to measure RNA binding specificity of CRISPR-Cas13d, revealing structural and sequence determinants of target recognition and enabling SNP detection in SARS-CoV-2 variants.

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas

The paper sequences 320 SARS-CoV-2 genomes from Houston to study early pandemic spread, finding diverse origins and no evidence of more virulent strains.