Beyond codon optimality: codon pairs regulate mRNA stability dependent on translation
Haejeong Lee, Damir Musaev, Charles E. Vejnar, Srikar Krishna, Trung Duc Nguyen, Ethan C. Strayer, Mario Abdelmessih, Carter M. Takacs, Jean-Denis Beaudoin, Antonio J. Giráldez
The paper identifies codon pairs and amino acid pairs as regulators of mRNA stability in zebrafish, showing context-dependent decay mechanisms involving deadenylation and decapping.
bioRxiv · Sep 17, 2026 · PreprintMolecular Biology