Author

Carter M. Takacs

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:multiome· 2

Frequent Co-Authors

Antonio J. GiráldeziD· 4 shared Charles E. VejnariD· 3 shared Jean-Denis BeaudoiniD· 3 shared Damir Musaev· 2 shared Mario AbdelmessihiD· 2 shared Valeria Yartseva· 2 shared Alejandro Díaz‐MoscosoiD· 1 shared Alejandro Sánchez AlvaradoiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMolecular Biology

Antonio J. GiráldezORCID

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Author profile →

5 papers

Recent·Most cited

Beyond codon optimality: codon pairs regulate mRNA stability dependent on translation

Haejeong Lee, Damir Musaev, Charles E. Vejnar, Srikar Krishna, Trung Duc Nguyen, Ethan C. Strayer, Mario Abdelmessih, Carter M. Takacs, Jean-Denis Beaudoin, Antonio J. Giráldez

The paper identifies codon pairs and amino acid pairs as regulators of mRNA stability in zebrafish, showing context-dependent decay mechanisms involving deadenylation and decapping.

bioRxiv · Sep 17, 2026 · PreprintMolecular Biology

CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

Gopal Kushawah, Luis Hernández-Huertas, Joaquín Abugattas-Núñez del Prado, Juan Ramón Martínez‐Morales, Michelle Lynn DeVore, Huzaifa Hassan, Ismael Moreno-Sánchez, Laura Tomás‐Gallardo, Alejandro Díaz‐Moscoso, Dahiana E. Monges, Javier R. Guelfo, William C. Theune, Emry O. Brannan, Wei Wang, Timothy J. Corbin, , Miguel A. Moreno-Mateos

This study demonstrates that CRISPR-Cas13d efficiently knocks down specific mRNAs in zebrafish, medaka, killifish, and mouse embryos, leading to significant transcript level reduction and embryonic phenotypes.

Developmental Cell · Aug 7, 2020Peer-reviewedDevelopmental Biology

A post-transcriptional regulatory code for mRNA stability during the zebrafish maternal-to-zygotic transition

Charles E. Vejnar, Mario Abdelmessih, Carter M. Takacs, Valeria Yartseva, Panos Oikonomou, Romain Christiano, Marlon Stoeckius, Stephanie Lau, Miler T. Lee, Jean-Denis Beaudoin, Damir Musaev, Hiba Darwich‐Codore, Tobias C. Walther, Saeed Tavazoie, Daniel Cifuentes, Antonio J. Giráldez

The paper identifies cis-regulatory elements and trans-factors governing mRNA stability during zebrafish MZT and develops a model to predict mRNA stability.

Genome Research · Jul 1, 2019Peer-reviewedGenomics

Genetic compensation is triggered by mutant mRNA degradation

Mohamed A. El-Brolosy, Zacharias Kontarakis, Andrea Rossi, Carsten Tobias Kuenne, Stefan Günther, Nana Fukuda, Khrievono Kikhi, Giulia L. M. Boezio, Carter M. Takacs, Shih-Lei Lai, Ryuichi Fukuda, Claudia Gerri, Antonio J. Giráldez, Didier Y. R. Stainier

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.

Nature · Apr 3, 2019Peer-reviewedGenetics

mRNA structure dynamics identifies the embryonic RNA regulome

Jean-Denis Beaudoin, Eva Maria Novoa, Charles E. Vejnar, Valeria Yartseva, Carter M. Takacs, M Kellis, Antonio J. Giráldez

The paper characterizes mRNA structure dynamics during zebrafish development and identifies ribosome-mediated RNA remodeling and 3-UTR structures as key regulators of gene expression and decay.

Nature Structural & Molecular Biology · Jul 19, 2018Peer-reviewedMolecular Biology