Jean-Denis Beaudoin

The paper identifies codon pairs and amino acid pairs as regulators of mRNA stability in zebrafish, showing context-dependent decay mechanisms involving deadenylation and decapping.

The paper uses single-molecule m6A profiling to study mRNA regulation during zebrafish MZT, finding m6A's role in mRNA decay and poly(A) tail dynamics.

NaP-TRAP measures translation and mRNA abundance to study cis-regulatory elements in mRNA stability and translation.

The paper compares RNA 2'-O-methylation patterns in neurons with and without specific snoRNA deletions, identifying new targets of orphan snoRNAs.

This study identifies how eIF4A1 differentially activates translation based on mRNA features, revealing distinct mechanisms for mRNA selection and inhibition by eFT226 and hippuristanol.

The paper introduces NaP-TRAP, a new MPRA method to measure mRNA translation, and uses it to analyze cis-regulatory elements in zebrafish and human cells.

Nano3P-seq quantifies RNA abundance, tail composition, and tail length dynamics at single-read resolution without PCR or adapters.

The paper identifies a functional non-coding RNA derived from xbp-1 mRNA cleavage in C. elegans neurons, showing it is essential for axon regeneration independent of the protein-coding function of xbp-1.

This paper shows that combining mutational profiles and drop-off information improves RNA structure analysis by capturing complementary structural information and reducing false positives.

The paper identifies cis-regulatory elements and trans-factors governing mRNA stability during zebrafish MZT and develops a model to predict mRNA stability.

The paper characterizes mRNA structure dynamics during zebrafish development and identifies ribosome-mediated RNA remodeling and 3-UTR structures as key regulators of gene expression and decay.

This study shows that Brd4 and P300 regulate zygotic genome activation through histone acetylation in zebrafish embryos.