Damir Musaev

Beyond codon optimality: codon pairs regulate mRNA stability dependent on translation

The paper identifies codon pairs and amino acid pairs as regulators of mRNA stability in zebrafish, showing context-dependent decay mechanisms involving deadenylation and decapping.

Novel cell states arise in embryonic cells devoid of key reprogramming factors

The paper investigates the developmental fate of zebrafish embryos lacking the reprogramming factors Nanog, Pou5f3, and Sox19b, finding that cells can acquire novel cell states or primordial germ cell-like states.

Genetically encoded affinity reagents (GEARs): A toolkit for visualizing and manipulating endogenous protein function in vivo.

This paper introduces GEARs, a toolkit for visualizing and manipulating endogenous proteins in vivo, demonstrating its use with Nanog and Vangl2 in zebrafish.

MINPP1 prevents intracellular accumulation of the cation chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia

This study identifies MINPP1 mutations as a cause of Pontocerebellar Hypoplasia, showing that MINPP1 deficiency leads to IP6 accumulation and cation chelation, disrupting brain development.

Quantification of autism recurrence risk by direct assessment of paternal sperm mosaicism

The paper quantifies autism recurrence risk by detecting paternal sperm mosaicism through single molecule genotyping and whole genome sequencing.

A post-transcriptional regulatory code for mRNA stability during the zebrafish maternal-to-zygotic transition

The paper identifies cis-regulatory elements and trans-factors governing mRNA stability during zebrafish MZT and develops a model to predict mRNA stability.

Brd4 and P300 regulate zygotic genome activation through histone acetylation

This study shows that Brd4 and P300 regulate zygotic genome activation through histone acetylation in zebrafish embryos.