Sustained loss of Pptc7 triggers variable skeletal muscle dysfunction and diminished body mass through dysregulation of BNIP3
Tessa Lochetto, Thiago N. Menezes, Kevin Cho, Srikar Vegesna, Michaela M. Morhaus, Jeremie L. A. Ferey, Merima Forny, Leah P. Shriver, Gretchen A. Meyer, Gary J. Patti, Natalie M. Niemi
This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.
bioRxiv · Jul 18, 2026 · PreprintPhysiology