Gary J. Patti

The paper develops XCiMS software to analyze LC-IMS-MS data and evaluates how ion mobility spectrometry improves untargeted metabolomics by reducing chimeric spectra and providing CCS values.

This study shows that diverse stresses cause periplasmic expansion in E. coli through distinct mechanisms, but UDP-glucose synthesis is required for expansion under some conditions.

This paper identifies a genetic bottleneck in the G3P shuttle that limits human developmental rate by constraining metabolic flux and the segmentation clock.

The paper identifies chemicals enriched for dementia-related genes and pathways using the Comparative Toxicogenomics Database, finding many chemicals associated with Alzheimer's disease and tauopathies.

This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.

This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.

The paper investigates the developmental and evolutionary origins of white pigment cells in cyprinid fishes, revealing convergent mechanisms across species.

The paper uses cell-specific isotope labeling to identify myo-inositol transfer from neurons to oligodendrocyte progenitor cells, promoting myelin repair and revealing a metabolic target for neurodegenerative disease therapy.

This study identifies glutamine as a key nitrogen source for Leptospira interrogans under physiological conditions and shows that targeting glutamine metabolism could inhibit bacterial proliferation and infection.

MassID provides near-complete metabolite annotation with probabilistic identification and FDR control in metabolomics data.

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

This study shows that overexpressing NAMPT in adipocytes protects against metabolic dysfunction in male obese mice but not females, via improved interorgan communication and extracellular vesicle effects.

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

This study shows that loss of dihydroceramide desaturase in glial cells causes neurodegeneration by disrupting ER and lipid droplet homeostasis, leading to neuronal death and developmental defects.

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.

The paper identifies BMP and Agouti signaling pathways that drive the transdifferentiation of melanophores to leucophores in zebrafish fins.

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

GEM-Net constructs multi-modal gene networks using harmonized omics data from the Long Life Family Study, revealing a microbiome-immune axis linked to metabolic health.

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

The paper proposes identification probability as an automated and transferable method to assess metabolite identification confidence in metabolomics.

This study shows that pyruvate supports neuronal viability without glucose and that mitochondrial pyruvate uptake regulates synaptic transmission in hippocampal terminals.

This study shows that a ketogenic diet improves heart failure in mice without requiring increased cardiac ketone metabolism.

The paper identifies ARHGAP44 as a novel gene associated with longitudinal changes in HbA1c in non-diabetic individuals using linkage and sequence analysis from two studies.

The paper shows that hematopoietic progenitors adjust to metabolic perturbations intrinsically to maintain homeostasis, independent of feedback from mature cells.

The paper introduces MPI-VGAE, a framework for predicting metabolite-protein interactions across organisms, showing improved performance in reconstructing metabolic pathways and disease-specific networks.

HERMES improves metabolite identification and structural annotation in mass spectrometry by using molecular formulas and avoiding peak detection.