Kevin Cho

The paper develops XCiMS software to analyze LC-IMS-MS data and evaluates how ion mobility spectrometry improves untargeted metabolomics by reducing chimeric spectra and providing CCS values.

This study shows that diverse stresses cause periplasmic expansion in E. coli through distinct mechanisms, but UDP-glucose synthesis is required for expansion under some conditions.

This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.

This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.

The paper uses cell-specific isotope labeling to identify myo-inositol transfer from neurons to oligodendrocyte progenitor cells, promoting myelin repair and revealing a metabolic target for neurodegenerative disease therapy.

MassID provides near-complete metabolite annotation with probabilistic identification and FDR control in metabolomics data.

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

This study shows that loss of dihydroceramide desaturase in glial cells causes neurodegeneration by disrupting ER and lipid droplet homeostasis, leading to neuronal death and developmental defects.

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

This study shows that a ketogenic diet improves heart failure in mice without requiring increased cardiac ketone metabolism.