Leah P. Shriver

The paper develops XCiMS software to analyze LC-IMS-MS data and evaluates how ion mobility spectrometry improves untargeted metabolomics by reducing chimeric spectra and providing CCS values.

This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.

The paper investigates the developmental and evolutionary origins of white pigment cells in cyprinid fishes, revealing convergent mechanisms across species.

The paper uses cell-specific isotope labeling to identify myo-inositol transfer from neurons to oligodendrocyte progenitor cells, promoting myelin repair and revealing a metabolic target for neurodegenerative disease therapy.

This study identifies glutamine as a key nitrogen source for Leptospira interrogans under physiological conditions and shows that targeting glutamine metabolism could inhibit bacterial proliferation and infection.

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

The paper identifies BMP and Agouti signaling pathways that drive the transdifferentiation of melanophores to leucophores in zebrafish fins.

GEM-Net constructs multi-modal gene networks using harmonized omics data from the Long Life Family Study, revealing a microbiome-immune axis linked to metabolic health.

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

This study shows that pyruvate supports neuronal viability without glucose and that mitochondrial pyruvate uptake regulates synaptic transmission in hippocampal terminals.