Durable reconstitution of sinonasal epithelium by transplant of CFTR gene corrected airway stem cells
Dawn T. Bravo, Sriram Vaidyanathan, Jeanette B Baker, Vrishti Sinha, Esmond F. Tsai, Pooya Roozdar, William W. Kong, Patrick J. Atkinson, Zara M. Patel, Peter H. Hwang, Vidya K. Rao, Robert S. Negrin, Jeffrey J. Wine, Carlos E. Milla, Zachary M. Sellers, , Jayakar V. Nayak
This study demonstrates that gene-corrected human airway stem cells can durably engraft and restore CFTR function in murine respiratory epithelium, offering a potential therapy for cystic fibrosis.
bioRxiv · Jan 24, 2025 · PreprintBioengineering