Author
University of California, Los AngelesORCID 0000-0002-2094-387XUnclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Ruth A. Foley, Paul George Ayoub, Vrishti Sinha…·Steven John Jonas
This paper develops lipid nanoparticles to deliver CRISPR/Cas9 for site-specific CFTR gene integration in CF airway cells, achieving 3-3.5% gene editing and 80% Cl- current restoration.
Vrishti Sinha, Paul George Ayoub, Colin J. Juett…·Donald B. Kohn
This study demonstrates that low levels of CFTR integration can restore chloride ion currents in human airway cells using optimized nonviral CRISPR-Cas9 RNP and double-stranded DNA donors.
Dawn T. Bravo, Sriram Vaidyanathan, Jeanette B Baker…·Jayakar V. Nayak
This study demonstrates that gene-corrected human airway stem cells can durably engraft and restore CFTR function in murine respiratory epithelium, offering a potential therapy for cystic fibrosis.
Commodore St Germain, Hongchang Zhao, Vrishti Sinha…·Jacqueline H. Barlow
The paper introduces TRIPn-Seq to identify transcription-replication interactions in mouse B cells, finding they correlate with replication stress and genomic instability.