Author

Sriram Vaidyanathan

Nationwide Children's HospitalORCID 0000-0001-9167-3056Unclaimed ORCID profile · follow to get notified of new preprints

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Sriram Vaidyanathan1 paper · Nationwide Children's Hospital

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:variant calling· 3 Assay:CRISPR screen· 2 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Estelle Cormet‐BoyakaiD· 2 shared Jacob T. StackiD· 2 shared Karen L Kanke· 2 shared Mark E. HesteriD· 2 shared Rachael E. RayneriD· 2 shared Reza NouriiD· 2 shared Tatyana A. VetteriD· 2 shared Afrooz RashnonejadiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetics

Estelle Cormet‐BoyakaORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 29, 2025

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Yasemin Sezgin, Genesis Snyder, Noushin Saljoughian…·Meisam Naeimi Kararoudi

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

DOI 10.1101/2025.05.29.641201

𝕏 PostBluesky

GeneticsMolecular Therapy — Nucleic AcidsPeer-reviewedSep 17, 2024

DNA-PKcs Inhibition Improves Sequential Gene Insertion of the Full-Length CFTR cDNA in Airway Stem Cells

Jacob T. Stack, Rachael E. Rayner, Reza Nouri…·Sriram Vaidyanathan

This study shows that inhibiting DNA repair pathways with AZD7648 improves gene insertion efficiency in airway stem cells for CFTR correction, but may introduce toxicity.

8 citations

humanCRISPR screen

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Molecular BiologybioRxivPreprintFeb 1, 2024

Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Gene Insertion in Primary Cells

Karen L Kanke, Rachael E. Rayner, Eli Abel…·Sriram Vaidyanathan

The paper demonstrates that chemically modified ssDNA (eDNA) significantly improves gene insertion efficiency in primary cells compared to unmodified ssDNA, achieving therapeutic levels in clinically relevant loci.

1 citation

humanCRISPR screen

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