Gcn5l1 governs heart-to-liver crosstalk in cardiometabolic heart failure by modulating cholesterol metabolism
Paramesha Bugga, Bellina A.S. Mushala, Michael Wayne Stoner, Janet R. Manning, Nisha Bhattarai, Maryam Sharifi‐Sanjani, Manling Zhang, Amber M. Vandevender, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, John Sembrat, Brett A. Kaufman, Sruti S Shiva, Cassandra L. Happe, Steven J. Mullett, , Iain Scott
This study identifies Gcn5l1 as a heart-specific factor that modulates cholesterol metabolism and heart-to-liver crosstalk in cardiometabolic heart failure, revealing the heart's role in systemic metabolic dysfunction.
bioRxiv · Feb 5, 2025 · PreprintPhysiology