Adenosylhomocysteinase drives epigenetic and metabolic reprogramming in ZFTA-RELA ependymoma
Navneesh Yadav, Olivia Pelcher, Raja Gopal Reddy Mooli, Robert B Cameron, Alberto Delaidelli, Kannan Boosi Narayana Rao, Bhagyalakshmi Manikandan, Senna Visser, Antonio C.T. Cobos, Vishal Parmar, Yuvraj Kayola, Siva Kumar Natarajan, Yash Patel, Jiao Zhang, Hardik Shah, , Kulandaimanuvel Antony Michealraj
This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.
bioRxiv · Oct 7, 2026 · PreprintCancer Biology