Adenosylhomocysteinase drives epigenetic and metabolic reprogramming in ZFTA-RELA ependymoma
Navneesh Yadav, Olivia Pelcher, Raja Gopal Reddy Mooli…·Kulandaimanuvel Antony Michealraj
This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.