Serotonin 5-HT2C receptor as a cellular target of PI3K inhibitor LY294002 and its analog LY303511
Polina D. Kotova, Ekaterina A. Dymova, Oleg O. Lyamin…·Stanislav S. Kolesnikov
This study shows that LY294002 and LY303511 affect serotonin-induced Ca2+ signaling via distinct mechanisms involving the 5-HT2C receptor, suggesting off-target effects beyond their intended PI3K inhibition.