Author

Oleg O. Lyamin

Institute of Cell BiophysicsORCID 0000-0002-1493-7676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Ekaterina A. DymovaiD· 2 shared Olga A. RogachevskajaiD· 2 shared Polina D. KotovaiD· 2 shared Stanislav S. Kolesnikov· 2 shared Evgeniya A. VoronovaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ekaterina A. DymovaORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 6, 2025

Serotonin 5-HT2C receptor as a cellular target of PI3K inhibitor LY294002 and its analog LY303511

Polina D. Kotova, Ekaterina A. Dymova, Oleg O. Lyamin…·Stanislav S. Kolesnikov

This study shows that LY294002 and LY303511 affect serotonin-induced Ca2+ signaling via distinct mechanisms involving the 5-HT2C receptor, suggesting off-target effects beyond their intended PI3K inhibition.

DOI 10.1101/2025.11.06.687025

mouseimaging

𝕏 PostBluesky

Pharmacology & ToxicologyBiochimica et Biophysica Acta (BBA) - General SubjectsPeer-reviewedMay 31, 2024

PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca2+ mobilization irrespectively of its primary target

Polina D. Kotova, Ekaterina A. Dymova, Oleg O. Lyamin…·Stanislav S. Kolesnikov

This study shows that the PI3K inhibitor PI828 blocks Ca2+ responses to aminergic agonists through an unknown mechanism unrelated to PI3K inhibition, while wortmannin has minimal effect.

2 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky