Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised Blood-Brain Barrier integrity
Ivan Bassi, Moshe Grunspan, Gideon Hen, Kishore Aravind Ravichandran, Noga Moshe, Laura Gutiérrez-Miranda, Stav Safriel, Daria Kostina, Amitay Shen, Carmen Ruiz de Almodóvar, Karina Yaniv
This study identifies endolysosomal dysfunction in radial glia progenitor cells as a cause of defective cerebral angiogenesis and BBB compromise in zebrafish, linking Notch3 processing defects to CSVD phenotypes.
Nature Communications · Sep 17, 2024Peer-reviewedDevelopmental Biology