ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
Maike Reinders, Bojana Kravić, Pinki Gahlot, Sandra Koska, Johannes van den Boom, Nina Schulze, Sophie Levantovsky, Stefan Kleine, Markus Kaiser, Yogesh Kulathu, Christian Behrends, Hemmo H Meyer
This study shows ATXN3 helps restore lysosomal function after damage by targeting K48-K63-branched ubiquitin chains on regenerating lysosomes.
The EMBO Journal · Jul 29, 2025Peer-reviewedCell Biology