Lysosome-Dependent Sphingolipid Regulation as a potential therapeutic Target for Cohen Syndrome
Fabrizio Vacca, Renuka Prasad, Huda Barakullah, Romain Da Costa, Stefania Vossio, Dimitri Moreau, Woong Sun, Howard Riezman, Muhammad Ansar
This study identifies small molecules that restore Golgi morphology and neurite outgrowth in Cohen Syndrome models by modulating sphingolipid metabolism.
bioRxiv · Sep 4, 2025 · PreprintCell Biology