Thierry Soldati

This study uses Dictyostelium discoideum to investigate host responses to Mycobacterium marinum infection, identifying Atg9's role in maintaining vacuole integrity and restricting bacterial growth.

This study identifies STAT-like proteins in Dictyostelium discoideum that regulate vacuole integrity and host defense against Mycobacterium marinum infection.

This study shows that EsxA initiates MCV membrane damage while PDIM amplifies lesions to cause catastrophic rupture, enabling bacterial escape.

The paper shows that lipid metabolism in mycobacteria is linked to their subcellular location, with FACL6 deletion disrupting lipid handling and reducing intracellular fitness.

This study identifies PefA, a Ca2+ sensor, as a regulator of ESCRT and autophagy responses to mycobacterial vacuole damage, showing its role in maintaining vacuolar integrity and infection outcomes.

This study shows that host membrane microdomains are essential for Mycobacterium marinum to cause membrane damage, escape into the cytosol, and infect cells.

This study shows mycobacteria shed surface components during early infection, which affect both infected and bystander host cells.

This paper introduces a high-throughput phenotypic host-pathogen assay using Dictyostelium discoideum and Mycobacterium marinum to screen anti-infective compounds, demonstrating its ability to differentiate between antibiotics and anti-infectives.

This study shows LAI-1, a signaling molecule from Legionella pneumophila, interacts with GBP in D. discoideum to inhibit migration and restrict bacterial growth.

This study identifies trans-δ-viniferins as promising anti-infective scaffolds against Mycobacterium marinum using a Dictyostelium discoideum infection model and natural product derivatives.

The paper characterizes the proteomic composition of Mycobacterium marinum-containing vacuoles in Dictyostelium discoideum at different infection stages and compares them to other mycobacterial compartments.

This study uses time-resolved RNA-seq to analyze D. discoideum gene expression during M. marinum infection, identifying key pathways involved in host response to damage, stress, and metabolic adaptation.