Nabil Hanna

Time-resolved transcriptomic profiling of Dictyostelium discoideum infection with Mycobacterium marinum reveals Atg9-dependent restriction via maintenance of vacuole integrity

This study uses Dictyostelium discoideum to investigate host responses to Mycobacterium marinum infection, identifying Atg9's role in maintaining vacuole integrity and restricting bacterial growth.

STAT transcription factors regulate host defences and vacuolar integrity during Mycobacterium marinum infection

This study identifies STAT-like proteins in Dictyostelium discoideum that regulate vacuole integrity and host defense against Mycobacterium marinum infection.

Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol and infection

This study shows that host membrane microdomains are essential for Mycobacterium marinum to cause membrane damage, escape into the cytosol, and infect cells.

The Dictyostelium discoideum - Mycobacterium marinum infection model, a powerful high throughput screening platform for anti-infective compounds

This paper introduces a high-throughput phenotypic host-pathogen assay using Dictyostelium discoideum and Mycobacterium marinum to screen anti-infective compounds, demonstrating its ability to differentiate between antibiotics and anti-infectives.

Discovery of anti-infective compounds against Mycobacterium marinum after biotransformation of simple natural stilbene scaffolds by a fungal secretome

This study identifies trans-δ-viniferins as promising anti-infective scaffolds against Mycobacterium marinum using a Dictyostelium discoideum infection model and natural product derivatives.

Time-resolved RNA-seq profiling of the infection of Dictyostelium discoideum by Mycobacterium marinum reveals an integrated host response to damage and stress

This study uses time-resolved RNA-seq to analyze D. discoideum gene expression during M. marinum infection, identifying key pathways involved in host response to damage, stress, and metabolic adaptation.