Dominant-negative TP53 mutations potentiated by the HSF1-regulatedproteostasis network
Stephanie Halim, Rebecca M. Sebastian, Kristi E. Liivak, Jessica E. Patrick, Tiffani Hui, David R. Amici, Andrew O. Giacomelli, Paulina Rios, Vincent L. Butty, William C. Hahn, Francisco J. Sánchez Rivera, Marc L. Mendillo, Yu‐Shan Lin, Matthew D. Shoulders
The paper shows that HSF1 activation supports the emergence of cancer-associated p53 mutations by enhancing their fitness under nutlin-3 pressure.
Molecular Cell · Jan 1, 2026Peer-reviewedMolecular Biology