Molecular BiologyMolecular CellPeer-reviewed
Dominant-negative TP53 mutations potentiated by the HSF1-regulatedproteostasis network
Stephanie Halim, Rebecca M. Sebastian, Kristi E. Liivak…·Matthew D. Shoulders
The paper shows that HSF1 activation supports the emergence of cancer-associated p53 mutations by enhancing their fitness under nutlin-3 pressure.
DOI 10.1016/j.molcel.2025.12.013