Andrew O. Giacomelli

The paper shows that HSF1 activation supports the emergence of cancer-associated p53 mutations by enhancing their fitness under nutlin-3 pressure.

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

The paper introduces a method to screen large variant libraries with mutations across wide regions using improved mutant detection software, enabling accurate variant calling and counting from sequencing data.

The paper uses Perturb-seq to assess the phenotypic impact of somatic variants in cancer, revealing a continuum of gain-of-function KRAS variants.