Marc L. Mendillo

The paper shows that HSF1 activation supports the emergence of cancer-associated p53 mutations by enhancing their fitness under nutlin-3 pressure.

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

This study identifies TIMM17A as a key mediator of HSF1-driven mitochondrial biogenesis and function in cancer cells, revealing a mechanism linking HSF1 to mitochondrial protein import and energy production.

This study identifies CRAMP1 as a selective regulator of histone H1 expression by interacting with GON4L in the histone locus body.

This study shows octopamine reprograms astrocytes to protect neurons from α-synuclein toxicity through metabolic pathways.

This study identifies RNA binding proteins as novel drivers of homologous recombination deficiency in tumors, expanding the known genetic causes beyond BRCA1/2 mutations.

The paper constructs a coessential genetic network to map the dynamic cellular stress response across 625 cancer cell lines, identifying key regulators and modules involved in stress resilience.