Targeted high-resolution chromosome conformation capture at genome-wide scale.
Damien J. Downes, Matthew E. Gosden, Jelena M. Telenius, Stephanie J. Carpenter, Lea Nußbaum, Sara De Ornellas, Martin J. Sergeant, Chris Q. Eijsbouts, Ron Schweßinger, Jon Kerry, Nigel A. Roberts, Arun Shivalingam, Afaf Helmy El-Sagheer, A. Marieke Oudelaar, Tom P Brown, , Jim R. Hughes
The paper introduces a new method, NuTi Capture-C, that improves high-resolution chromosome conformation capture by reducing noise and increasing sequencing content, enabling reproducible genome-wide interaction profiles.
bioRxiv · Mar 2, 2020 · PreprintGenomics