Found in Transcription: Gene fusions arise through defects in RNA processing in the absence of chromosomal rearrangements.
Yue Jiang, Michael J. Apostolides, Mia Husić, Robert Siddaway, Man Yu, Stephanie Mark, Arun K Ramani, Cynthia E Hawkins, Michael Brudno
The paper identifies RNA-specific gene fusions in tumors and normal tissues, showing they are linked to spliceosomal gene dysregulation and may contribute to cancer development.
bioRxiv · Oct 30, 2019 · PreprintGenomics