Thorsten Wiech

The paper identifies an injury-induced complement program in kidney cells that couples inflammation to metabolism and chromatin regulation, promoting maladaptive fibrosis.

This study uses spatial transcriptomics to show that immune and renal cell interactions drive glomerular crescent formation in RPGN through PDGF and TGF-β signaling to PECs.

The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.

This study identifies MAGI2 as a conserved biomarker for podocyte injury, showing its downregulation in glomerular diseases and differential expression in primary vs secondary FSGS.

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.

This study uses single-cell RNA sequencing to identify a mechanosensitive MRTF-SRF pathway in early diabetic nephropathy, validated in human datasets and ex vivo experiments.