Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates
Ellie Paige, Marc Clément, Fabien Lareyre, Michael J. Sweeting, Juliette Raffort, Céline Grenier, Alison J. Finigan, James E. Harrison, James E. Peters, Benjamin B. Sun, Adam S. Butterworth, Seamus C. Harrison, Matthew J. Bown, Jes Sanddal Lindholt, Stephen A. Badger, , Ziad Mallat
The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.
Circulation Genomic and Precision Medicine · Feb 1, 2019Peer-reviewedGenetics