ITAF45 is a Pervasive Trans Acting Factor for Picornavirus Type II IRES Elements
Michael A. Bellucci, Mehdi Amiri, Stephen Berryman, Andia Moshari, Collins Oduor Owino, Rutger David Luteijn, Tobias J. Tuthill, Yuri V. Svitkin, Graham J. Belsham, Frank J. M. van Kuppeveld, Nahum Sonenberg
The paper identifies ITAF45 as a host factor essential for picornavirus Type II IRES-mediated translation, showing its role in multiple viruses and suggesting it as an antiviral target.
Proceedings of the National Academy of Sciences · Aug 11, 2025Peer-reviewedMicrobiology