Frank J. M. van Kuppeveld

The paper determines the structure of norovirus NS3 and proposes it functions as an RNA translocase.

This study identifies spike and host glycan determinants of HKU1 airway tropism by showing preferential binding to 9-O-acetylated 2,8-linked disialosides and structural insights into ligand recognition.

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

This study presents cryo-EM structures of cetacean coronavirus S proteins, revealing unique structural features and glycosylation patterns that highlight structural plasticity and host adaptation.

This study shows that cardiovirus L protein disrupts nucleocytoplasmic trafficking, leading to PKR inhibition by sequestering PKR in nucleoli and releasing nuclear RNA-binding proteins into the cytosol.

This paper determines the structure of the EEHV1A gH/gL/gO complex and shows it functions as the receptor-binding complex for EEHV1A.

The paper identifies ITAF45 as a host factor essential for picornavirus Type II IRES-mediated translation, showing its role in multiple viruses and suggesting it as an antiviral target.

This study identifies picornavirus proteins that inhibit de novo nucleotide synthesis during infection using metabolomics and recombinant virus analysis.

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

This study demonstrates that enterovirus 2A protease is critical for viral replication and evasion of host antiviral responses through multiple mechanisms.

This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.